Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes

Biomarkers. 2014 Sep;19(6):493-7. doi: 10.3109/1354750X.2014.940502. Epub 2014 Jul 14.


Objective: To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.

Methods: A cross-sectional cohort study.

Results: In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).

Conclusions: Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.

Keywords: Diabetes; hyaluronan; vascular function.

MeSH terms

  • Aged
  • Biomarkers / blood
  • Brachial Artery / physiopathology
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Female
  • Humans
  • Hyaluronic Acid / blood*
  • Male
  • Middle Aged
  • Vasodilation*


  • Biomarkers
  • Hyaluronic Acid