Context: Nectin 4 plays a significant role in cancer cell growth and invasion.
Objective: To explore its diagnostic role in ovarian cancer.
Materials and methods: Evaluation of nectin 4 expression in ovarian biopsies by real-time PCR and serum nectin 4 and CA-125 by ELISA in 39 ovarian cancer patients, 21 females with benign ovarian neoplasms and 25 control females.
Results: Nectin 4 expression was significantly higher in ovarian cancer patients and it was significantly correlated to serum nectin 4 and CA-125.
Conclusions: Ovarian tissue expression and serum nectin 4 appear to be potential markers in ovarian cancer.
Keywords: CA-125; marker; nectin 4; ovarian cancer.