Reducing risks in type 1 diabetes using H∞ control

IEEE Trans Biomed Eng. 2014 Dec;61(12):2939-47. doi: 10.1109/TBME.2014.2336772. Epub 2014 Jul 9.


A control scheme was designed in order to reduce the risks of hyperglycemia and hypoglycemia in type 1 diabetes mellitus (T1DM). This structure is composed of three main components: an H∞ robust controller, an insulin feedback loop (IFL), and a safety mechanism (SM). A control-relevant model that is employed to design the robust controller is identified. The identification procedure is based on the distribution version of the UVA/Padova metabolic simulator using the simulation adult cohort. The SM prevents dangerous scenarios by acting upon a prediction of future glucose levels, and the IFL modifies the loop gain in order to reduce postprandial hypoglycemia risks. The procedure is tested on the complete alic>in silico adult cohort of the UVA/Padova metabolic simulator, which has been accepted by the Food and Drug Administration (FDA) in lieu of animal trials.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Blood Glucose / metabolism*
  • Computer Simulation
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Drug Therapy, Computer-Assisted / methods*
  • Feedback, Physiological
  • Female
  • Humans
  • Insulin / administration & dosage*
  • Insulin / blood*
  • Male
  • Models, Biological
  • Pancreas, Artificial*
  • Reproducibility of Results
  • Risk Reduction Behavior
  • Sensitivity and Specificity


  • Blood Glucose
  • Insulin