[Efficacy comparison of menopausal irritability between acupuncture and medication: a randomized controlled trial]

Zhongguo Zhen Jiu. 2014 May;34(5):455-8.
[Article in Chinese]


Objective: To observe the differences in the clinical efficacy on menopausal irritability between acupuncture and medication.

Methods: Sixty cases of menopausal irritability were randomized into an acupuncture group (31 cases) and a medication group (29 cases). In the acupuncture group, the warming needling manipulation was applied at the key acupoints such as Hegu (LI 4) and Taichong (LR 3), once a day, 10 treatments made one session. Totally, 2 sessions were required. In the medication group, 2.5 mg diazepam tablets were prescribed, three times a day, for 23 days totally. The clinical efficacy, the modified Kupperman score and self-rated health measurement scale (SRHMS) were compared before and after treatment in the two groups. RESULTS The total effective rate was 87. 1% (27/31) in the acupuncture group and 82.8% (24/29) in the medication group. The difference in the clinical efficacy was not significant between the two groups (P > 0.05). The modified Kupperman score and SRHMS score were both reduced obviously after treatment in the two groups, indicating the significant difference (all P < 0.05). The reduction of two scores in the acupuncture group was more obvious than those in the medication group (Kupperman: 15.23 +/- 6.19 vs 18.45 +/- 5.37; SRHMS: 116.29 +/- 38.24 vs 140.34 +/- 42.15, both P < 0.05).

Conclusion: The acupuncture and medication are effective in the treatment of menopausal irritability, but the efficacy of warming needling manipulation is better than that of diazepam tablets.

Publication types

  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acupuncture Therapy*
  • Adult
  • Anti-Anxiety Agents / administration & dosage*
  • Anxiety / drug therapy
  • Anxiety / psychology
  • Anxiety / therapy*
  • Diazepam / administration & dosage*
  • Female
  • Humans
  • Menopause / drug effects
  • Menopause / psychology*
  • Middle Aged
  • Treatment Outcome


  • Anti-Anxiety Agents
  • Diazepam