Donor cell-derived myelodysplastic syndrome with ring chromosome 7 after allogeneic hematopoietic stem cell transplant in 2 patients with lymphomas as primary disease

Clin Lymphoma Myeloma Leuk. 2014 Oct;14(5):e151-5. doi: 10.1016/j.clml.2014.04.003. Epub 2014 Jun 10.

Authors

Amir Hamdi¹, Aimaz Afrough¹, Tariq Muzzafar², Uday R Popat¹, Chitra M Hosing¹, Muzaffar H Qazilbash¹, Gary Lu³

Affiliations

¹ Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX.
² Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX.
³ Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: gglu@mdanderson.org.

PMID: 25022600
DOI: 10.1016/j.clml.2014.04.003

No abstract available

Keywords: Donor cells; MDS; Ring chromosome 7.

Publication types

Case Reports

MeSH terms

Allografts
Antibodies, Monoclonal / administration & dosage
Antibodies, Monoclonal, Murine-Derived / administration & dosage
Biomarkers, Tumor
Bone Marrow / pathology
Cell Transformation, Neoplastic / genetics*
Chromosome Deletion*
Chromosomes, Human, Pair 7 / genetics
Chromosomes, Human, Pair 7 / ultrastructure*
Cyclophosphamide / administration & dosage
Disease Progression
ETS Translocation Variant 6 Protein
Female
Gene Deletion*
Humans
In Situ Hybridization, Fluorescence
Leukemia, Myeloid, Acute / etiology*
Leukemia, Myeloid, Acute / genetics
Leukemia, Myeloid, Acute / pathology
Living Donors
Lymphoma, Follicular / drug therapy
Lymphoma, Follicular / therapy*
Lymphoma, Mantle-Cell / drug therapy
Lymphoma, Mantle-Cell / therapy*
Male
Middle Aged
Myelodysplastic Syndromes / etiology*
Myelodysplastic Syndromes / genetics
Myelodysplastic Syndromes / pathology
Neoplasms, Second Primary / etiology*
Neoplasms, Second Primary / pathology
Peripheral Blood Stem Cell Transplantation*
Proto-Oncogene Proteins c-ets / deficiency
Proto-Oncogene Proteins c-ets / genetics
Repressor Proteins / deficiency
Repressor Proteins / genetics
Ring Chromosomes*
Rituximab
Transplantation Chimera / genetics
Vidarabine / administration & dosage
Vidarabine / analogs & derivatives

Substances

Antibodies, Monoclonal
Antibodies, Monoclonal, Murine-Derived
Biomarkers, Tumor
Proto-Oncogene Proteins c-ets
Repressor Proteins
Rituximab
ibritumomab tiuxetan
Cyclophosphamide
Vidarabine
fludarabine