Dock-family exchange factors in cell migration and disease

Eur J Cell Biol. 2014 Oct;93(10-12):466-77. doi: 10.1016/j.ejcb.2014.06.003. Epub 2014 Jun 24.


Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 that play different cellular functions. In particular, Dock proteins regulate actin cytoskeleton, cell adhesion and migration. Not surprisingly, members of the Dock family have been involved in various pathologies, including cancer and defects in the central nervous and immune systems. This review proposes an update of the recent findings regarding the function of Dock proteins, focusing on their role in the control of cell migration and invasion and the consequences in human diseases.

Keywords: Adhesion; Amoeboid; Cancer; Cdc42; DHR2; Dock1; Dock10; Dock11; Dock180; Dock2; Dock3; Dock4; Dock5; Dock6; Dock7; Dock8; Dock9; Exchange factor; GPCR; Integrin; Migration; Osteoclast; Rac1; Rho GTPase; Synapse; Zizimin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism
  • Animals
  • Axons / metabolism
  • Bone Resorption / metabolism
  • Cell Adhesion
  • Cell Movement
  • Guanine Nucleotide Exchange Factors / genetics
  • Guanine Nucleotide Exchange Factors / metabolism*
  • Humans
  • Immune System / physiology
  • Neoplasm Invasiveness
  • Neoplasms / pathology
  • Osteoclasts / metabolism
  • Signal Transduction
  • cdc42 GTP-Binding Protein / metabolism
  • rho GTP-Binding Proteins / metabolism


  • Guanine Nucleotide Exchange Factors
  • cdc42 GTP-Binding Protein
  • rho GTP-Binding Proteins