Interactions between anticancer trans-platinum compounds and proteins: crystal structures and ESI-MS spectra of two protein adducts of trans-(dimethylamino)(methylamino)dichloridoplatinum(II)

Inorg Chem. 2014 Aug 4;53(15):7806-8. doi: 10.1021/ic5012583. Epub 2014 Jul 15.


The adducts formed between trans-(dimethylamino)(methylamino)dichloridoplatinum(II), [t-PtCl2(dma)(ma)], and two model proteins, i.e., hen egg white lysozyme and bovine pancreatic ribonuclease, were independently characterized by X-ray crystallography and electrospray ionization mass spectrometry. In these adducts, the Pt(II) center, upon chloride release, coordinates either to histidine or aspartic acid residues while both alkylamino ligands remain bound to the metal. Comparison with the cisplatin derivatives of the same proteins highlights for [t-PtCl2(dma)(ma)] a kind of biomolecular metalation remarkably different from that of cisplatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Cattle
  • Crystallography, X-Ray
  • Muramidase / chemistry
  • Platinum Compounds / chemistry*
  • Proteins / chemistry*
  • Ribonuclease, Pancreatic / chemistry
  • Spectrometry, Mass, Electrospray Ionization


  • Antineoplastic Agents
  • Platinum Compounds
  • Proteins
  • Ribonuclease, Pancreatic
  • hen egg lysozyme
  • Muramidase