Endothelial cells in dengue hemorrhagic fever

Antiviral Res. 2014 Sep;109:160-70. doi: 10.1016/j.antiviral.2014.07.005. Epub 2014 Jul 12.


Therapies to prevent or reverse endothelial dysfunction and vascular leak found in dengue hemorrhagic fever (DHF) have not been identified. In this review we summarize dengue viruses and the spectrum of human disease and highlight evidence of endothelial cell dysfunction in DHF based on studies in patients and mouse and tissue culture models. Evidence suggests that both virus antigen and host immune response, can cause endothelial cell dysfunction and weaken endothelial barrier integrity. We suggest possible therapeutic interventions and highlight how therapies targeting altered endothelial function might be evaluated in animal models and in patients with DHF.

Keywords: Dengue hemorrhagic fever; Dengue virus; Endothelial barrier integrity; Endothelial cells; Vascular leak.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology
  • Dengue Virus / drug effects
  • Dengue Virus / physiology*
  • Endothelial Cells / immunology
  • Endothelial Cells / virology*
  • Endothelium, Vascular / immunology
  • Endothelium, Vascular / virology
  • Humans
  • Severe Dengue / immunology
  • Severe Dengue / therapy
  • Severe Dengue / virology*


  • Antiviral Agents