Anti arthritic and anti inflammatory activity of a cytotoxic protein NN-32 from Indian spectacle cobra (Naja naja) venom in male albino rats

Toxicon. 2014 Nov:90:106-10. doi: 10.1016/j.toxicon.2014.07.002. Epub 2014 Jul 12.

Abstract

The anti arthritic and anti inflammatory activity of NN-32, a cytotoxic protein from Indian spectacle cobra snake (Naja naja) venom has been studied in Freund's complete adjuvant (FCA) induced arthritis and carrageenan induced anti inflammatory model. NN-32 treatment showed significant decrease in physical and urinary parameters, serum enzymes, serum cytokines levels as compared to arthritic control group of rats. NN-32 treatment recovered carrageenan induced inflammation as compared to control group of rats. The findings showed that the cytotoxic protein NN-32 shares anti arthritic and anti inflammatory activity and thus NN-32 may target complex pathophysiological processes like cancer- arthritis-inflammation.

Keywords: Cytotoxic protein; Indian Naja naja venom; Rheumatoid arthritis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Arthritis / drug therapy*
  • Elapid Venoms / chemistry*
  • Elapidae
  • Male
  • Proteins / pharmacology*
  • Proteins / therapeutic use
  • Rats

Substances

  • Anti-Inflammatory Agents
  • Elapid Venoms
  • Proteins