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Review
. 2014 Oct;92(10):1025-34.
doi: 10.1007/s00109-014-1166-x. Epub 2014 Jun 12.

Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia

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Review

Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia

Sergiu-Bogdan Catrina. J Mol Med (Berl). 2014 Oct.

Abstract

The mechanisms that contribute to the development of diabetes complications remain unclear. A defective reaction of tissues to hypoxia has recently emerged as a new pathogenic mechanism and consists of a complex repression of hypoxia-inducible factor (HIF), which is the main regulator of the adaptive response to hypoxia. This paper discusses the mechanisms by which hyperglycaemia contributes to HIF repression in diabetes. Furthermore, a comprehensive analysis of the functional relevance of these new findings to the development of chronic diabetes complications is provided, along with examples from animal models and clinics.

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