Lunasin as a promising health-beneficial peptide

Eur Rev Med Pharmacol Sci. 2014;18(14):2070-5.


Lunasin, a 43 amino acid polypeptide originally isolated from soybean, is known to produce multiple health benefits, including anti-hypertension, antioxidant activity, cancer prevention or therapy, anti-inflammation, hypocholesterolemic activity, anti-obesity and immunomodulation. These effects are believed to be due to its unique structure that includes a putative helical region, an Arg-Gly-Asp (RGD) motif and an Asp-rich carboxyl terminus. The focus of this article is to summarize the discovery, characterization and biological activities of lunasin, which will provide a reference for the future development and utilization of lunasin, and a basis for exploring the underlying mechanisms of these health-beneficial functions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Oligopeptides / chemistry
  • Peptide Fragments / chemistry*
  • Peptide Fragments / pharmacology*
  • Soybean Proteins / chemistry*
  • Soybean Proteins / pharmacology*
  • Soybeans / chemistry


  • GM2S-1 protein, soybean
  • Oligopeptides
  • Peptide Fragments
  • Soybean Proteins
  • arginyl-glycyl-aspartic acid