Review of casein phosphopeptides-amorphous calcium phosphate

Chin J Dent Res. 2014;17(1):7-14.


Casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) is a bioactive agent with a base of milk products, which has been formulated from two parts: casein phosphopeptides (CPP) and amorphous calcium phosphate (ACP). CPP was produced from milk protein casein and has a remarkable ability to stabilize calcium phosphate in solution and to substantially increase the level of calcium phosphate in dental plaque. CPP-ACP buffers the free calcium and phosphate ion activities, thereby helping to maintain a state of supersaturation with respect to tooth enamel, reducing demineralisation and promoting remineralisation. The free calcium and phosphate ions move out of the CPP, enter the enamel rods and reform onto apatite crystals. Laboratory, animal and human studies have shown that CPP-ACP inhibits cariogenic activity. CPP-ACP is useful in the treatment of white spot lesions, hypomineralised enamel, mild fluorosis, tooth sensitivity and erosion, and prevents plaque accumulation around brackets and other orthodontic appliances. CPP-ACP also facilitates a normal post-eruptive maturation process and is ideal for protecting primary teeth at a time when oral care is difficult. CPP-ACP has commercial potential as an additive to foods, soft drinks and chewing gum, as well as additive to toothpastes and mouthwashes to control dental caries.

Publication types

  • Review

MeSH terms

  • Calcium Phosphates / pharmacokinetics
  • Cariostatic Agents / therapeutic use*
  • Caseins / therapeutic use*
  • Dental Enamel / drug effects
  • Dental Plaque / metabolism
  • Humans
  • Protective Agents / therapeutic use
  • Tooth Remineralization / methods
  • Tooth, Deciduous / drug effects


  • Calcium Phosphates
  • Cariostatic Agents
  • Caseins
  • Protective Agents
  • casein phosphopeptide-amorphous calcium phosphate nanocomplex
  • calcium phosphate