Aspirin-induced acute haemolytic anaemia in glucose-6-phosphate dehydrogenase-deficient children with systemic arthritis

Acta Haematol. 1989;81(4):208-9. doi: 10.1159/000205562.


In a 4-year 7-month-old boy with glucose-6-phosphate dehydrogenase deficiency and systemic arthritis a severe haemolytic anaemia occurred after the administration of acetylsalicylic acid. Erythrocyte fragmentation, with haemoglobin condensation zones next to clear zones, was observed on peripheral blood smears. Since viral or bacterial infections were excluded on the basis of the laboratory data, the anaemia was ascribed to aspirin.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Hemolytic / blood
  • Anemia, Hemolytic / chemically induced*
  • Arthritis / blood
  • Arthritis / complications*
  • Arthritis / drug therapy
  • Aspirin / adverse effects*
  • Child, Preschool
  • Glucosephosphate Dehydrogenase Deficiency / blood
  • Glucosephosphate Dehydrogenase Deficiency / complications*
  • Humans
  • Male


  • Aspirin