The thinning top: why old people have less hair

doi:10.1038/jid.2014.172

Comment

. 2014 Aug;134(8):2068-2069.

doi: 10.1038/jid.2014.172.

The thinning top: why old people have less hair

Sashank K Reddy¹, Luis A Garza²

Affiliations

¹ Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: LAG@jhmi.edu.

PMID: 25029319
PMCID: PMC4101907
DOI: 10.1038/jid.2014.172

Comment

The thinning top: why old people have less hair

Sashank K Reddy et al. J Invest Dermatol. 2014 Aug.

. 2014 Aug;134(8):2068-2069.

doi: 10.1038/jid.2014.172.

Authors

Sashank K Reddy¹, Luis A Garza²

Affiliations

¹ Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: LAG@jhmi.edu.

PMID: 25029319
PMCID: PMC4101907
DOI: 10.1038/jid.2014.172

Abstract

Changes in the hair cycle underlie age-related alopecia, but the causative mechanisms have remained unclear. Chen et al. point to an imbalance between stem cell-activating and -inhibitory signals as the key determinant of age-related regenerative decline. Further, they identify a secreted protein, follistatin, that may be able to shift the balance toward renewal.

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Comment on

Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4.
Chen CC, Murray PJ, Jiang TX, Plikus MV, Chang YT, Lee OK, Widelitz RB, Chuong CM. Chen CC, et al. J Invest Dermatol. 2014 Aug;134(8):2086-2096. doi: 10.1038/jid.2014.139. Epub 2014 Mar 11. J Invest Dermatol. 2014. PMID: 24618599 Free PMC article.

References

1. Alonso L, Fuchs E. The hair cycle. Journal of cell science. 2006;119:391–3. - PubMed
1. Chase HB. Growth of the hair. Physiological reviews. 1954;34:113–26. - PubMed
1. Chen CC, Murray PJ, Jiang TX, et al. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1 and Sfrp4. The Journal of investigative dermatology 2014 - PMC - PubMed
1. Drake DB, Persing JA, Berman DE, et al. Calvarial deformity regeneration following subtotal craniectomy for craniosynostosis: a case report and theoretical implications. The Journal of craniofacial surgery. 1993;4:85–9. discussion 90. - PubMed
1. Garza LA, Yang CC, Zhao T, et al. Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. The Journal of clinical investigation. 2011;121:613–22. - PMC - PubMed

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[1] Alonso L, Fuchs E. The hair cycle. Journal of cell science. 2006;119:391–3. - PubMed

[2] Alonso L, Fuchs E. The hair cycle. Journal of cell science. 2006;119:391–3. - PubMed

[3] Chase HB. Growth of the hair. Physiological reviews. 1954;34:113–26. - PubMed

[4] Chase HB. Growth of the hair. Physiological reviews. 1954;34:113–26. - PubMed

[5] Chen CC, Murray PJ, Jiang TX, et al. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1 and Sfrp4. The Journal of investigative dermatology 2014 - PMC - PubMed

[6] Chen CC, Murray PJ, Jiang TX, et al. Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1 and Sfrp4. The Journal of investigative dermatology 2014 - PMC - PubMed

[7] Drake DB, Persing JA, Berman DE, et al. Calvarial deformity regeneration following subtotal craniectomy for craniosynostosis: a case report and theoretical implications. The Journal of craniofacial surgery. 1993;4:85–9. discussion 90. - PubMed

[8] Drake DB, Persing JA, Berman DE, et al. Calvarial deformity regeneration following subtotal craniectomy for craniosynostosis: a case report and theoretical implications. The Journal of craniofacial surgery. 1993;4:85–9. discussion 90. - PubMed

[9] Garza LA, Yang CC, Zhao T, et al. Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. The Journal of clinical investigation. 2011;121:613–22. - PMC - PubMed

[10] Garza LA, Yang CC, Zhao T, et al. Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. The Journal of clinical investigation. 2011;121:613–22. - PMC - PubMed

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The thinning top: why old people have less hair

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The thinning top: why old people have less hair

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