Standardization and quantification in FDG-PET/CT imaging for staging and restaging of malignant disease

PET Clin. 2014 Apr;9(2):117-27. doi: 10.1016/j.cpet.2013.10.003. Epub 2013 Dec 5.


There is a growing interest in using quantification in FDG-PET/CT in oncology, especially for evaluating response to therapy. Complex full quantitative procedures with blood sampling and dynamic scanning have been clinically replaced by the use of standardized uptake value measurements that provide an index of regional tracer uptake normalized to the administered dose of FDG. Some approaches have been proposed for assessing quantitative metabolic response, such as EORTC and PERCIST criteria in solid tumors. When using standardized uptake value in clinical routine and multicenter trials, standardization of protocols and quality control procedures of instrumentation is required.

Keywords: Cancer; FDG; PET/CT; Quality control; Quantification; SUV; Standardization.

Publication types

  • Review

MeSH terms

  • Calibration
  • Equipment Failure
  • Fluorodeoxyglucose F18*
  • Humans
  • Medical Errors
  • Multimodal Imaging / methods
  • Multimodal Imaging / standards*
  • Neoplasm Staging
  • Neoplasms / diagnostic imaging*
  • Neoplasms / pathology
  • Positron-Emission Tomography / instrumentation
  • Positron-Emission Tomography / methods
  • Positron-Emission Tomography / standards*
  • Quality Control
  • Radiometry
  • Radiopharmaceuticals*
  • Tomography, X-Ray Computed / methods
  • Tomography, X-Ray Computed / standards*
  • Treatment Outcome


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18