Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis

Arch Dermatol Res. 2014 Dec;306(10):933-8. doi: 10.1007/s00403-014-1488-0. Epub 2014 Jul 17.

Abstract

Acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) are rare pustular skin disorders with systemic involvement. IL-17A/F is a proinflammatory cytokine involved in various neutrophilic inflammatory disorders. Here we show that IL-17A/F is highly expressed by innate immune cells such as neutrophils and mast cells in both AGEP and GPP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Generalized Exanthematous Pustulosis / genetics
  • Acute Generalized Exanthematous Pustulosis / immunology
  • Acute Generalized Exanthematous Pustulosis / metabolism*
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Humans
  • Immunity, Innate*
  • Inflammation Mediators / immunology
  • Inflammation Mediators / metabolism*
  • Interleukin-17 / genetics
  • Interleukin-17 / immunology
  • Interleukin-17 / metabolism*
  • Male
  • Mast Cells / immunology
  • Mast Cells / metabolism*
  • Middle Aged
  • Neutrophils / immunology
  • Neutrophils / metabolism*
  • Psoriasis / genetics
  • Psoriasis / immunology
  • Psoriasis / metabolism*
  • RNA, Messenger / metabolism
  • Signal Transduction
  • Skin / immunology
  • Skin / metabolism*
  • Young Adult

Substances

  • IL17A protein, human
  • IL17F protein, human
  • Inflammation Mediators
  • Interleukin-17
  • RNA, Messenger