Abstract
This study documents that mumps virus shares several peptide sequences with human proteins that, when altered, may be involved in oligospermia/azoospermia, sterility and testicular atrophy. Examples are sperm flagellar protein 2 and spermatogenesis and centriole-associated protein 1. The data invite to further investigate crossreactivity as a potential mechanism linking anti-mumps immune responses, alterations of spermatogenesis-associated antigens and male fertility disorders.
MeSH terms
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Antigens, Viral / chemistry
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Antigens, Viral / immunology*
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Cross Reactions
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Humans
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Infertility, Male / immunology
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Infertility, Male / virology
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Male
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Mumps virus / immunology*
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Peptide Fragments / chemistry
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Peptide Fragments / immunology
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Proteome / analysis*
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Proteome / immunology
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Seminal Plasma Proteins / chemistry
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Seminal Plasma Proteins / immunology*
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Sequence Alignment
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Sequence Analysis, Protein
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Spermatogenesis* / immunology
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Viral Proteins / chemistry
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Viral Proteins / immunology
Substances
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Antigens, Viral
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Peptide Fragments
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Proteome
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Seminal Plasma Proteins
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Viral Proteins