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. 2014 Aug;14(8):547-58.
doi: 10.1038/nrc3773. Epub 2014 Jul 17.

Inside and Out: The Activities of Senescence in Cancer


Inside and Out: The Activities of Senescence in Cancer

Pedro A Pérez-Mancera et al. Nat Rev Cancer. .


The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality. Both the cell-autonomous and the non-cell-autonomous activities of senescent cells create spatiotemporally dynamic and context-dependent tissue reactions. For example, the senescence-associated secretory phenotype (SASP) provokes not only tumour-suppressive but also tumour-promoting responses. Senescence is now increasingly considered to be an integrated and widespread component that is potentially important for tumour development, tumour suppression and the response to therapy.

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