First isolate of KPC-2-producing Klebsiella pneumonaie sequence type 23 from the Americas

J Clin Microbiol. 2014 Sep;52(9):3483-5. doi: 10.1128/JCM.00726-14. Epub 2014 Jul 16.

Abstract

KPC-2-producing Klebsiella pneumoniae isolates mainly correspond to clonal complex 258 (CC258); however, we describe KPC-2-producing K. pneumoniae isolates belonging to invasive sequence type 23 (ST23). KPC-2 has scarcely been reported to occur in ST23, and this report describes the first isolation of this pathogen in the Americas. Acquisition of resistant markers in virulent clones could mark an evolutionary step toward the establishment of these clones as major nosocomial pathogens.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Americas
  • Bacteriological Techniques
  • Evolution, Molecular
  • Gene Order
  • Genes, Bacterial
  • Genotype
  • Humans
  • Klebsiella Infections / diagnosis*
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / classification*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification*
  • Male
  • Molecular Typing*
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • beta-Lactamases
  • beta-lactamase KPC-2, Klebsiella pneumoniae