Why epistasis is important for tackling complex human disease genetics

Genome Med. 2014 Jun 9;6(6):124. doi: 10.1186/gm561. eCollection 2014.


Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex disease.