Diversity and specificity: auxin perception and signaling through the TIR1/AFB pathway

Curr Opin Plant Biol. 2014 Oct;21:51-58. doi: 10.1016/j.pbi.2014.06.006. Epub 2014 Jul 15.


Auxin is a versatile plant hormone that plays an essential role in most aspects of plant growth and development. Auxin regulates various growth processes by modulating gene transcription through a SCF(TIR1/AFB)-Aux/IAA-ARF nuclear signaling module. Recent work has generated clues as to how multiple layers of regulation of the auxin signaling components may result in diverse and specific response outputs. In particular, interaction and structural studies of key auxin signaling proteins have produced novel insights into the molecular basis of auxin-regulated transcription and may lead to a refined auxin signaling model.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Arabidopsis / growth & development
  • Arabidopsis / physiology
  • Arabidopsis Proteins / physiology*
  • F-Box Proteins / physiology*
  • Gene Expression Regulation, Plant / physiology
  • Indoleacetic Acids / metabolism*
  • Plant Growth Regulators / physiology*
  • Receptors, Cell Surface / physiology*
  • Signal Transduction / physiology*


  • Arabidopsis Proteins
  • F-Box Proteins
  • Indoleacetic Acids
  • Plant Growth Regulators
  • Receptors, Cell Surface
  • TIR1 protein, Arabidopsis