A highly selective water-soluble optical probe for endogenous peroxynitrite

Chem Commun (Camb). 2014 Sep 7;50(69):9947-50. doi: 10.1039/c4cc04192e.

Abstract

A colorimetric and fluorescent probe C-Py-1 for ONOO(-) was prepared and it could exhibit high sensitivity and excellent selectivity toward ONOO(-) among reactive oxygen species (ROS) and reactive nitrogen species (RNS) with a rapid response time in 100% water solution. Meanwhile, C-Py-1 was successfully applied in the imaging of endogenous ONOO(-) in RAW264.7 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Fluorescent Dyes / chemistry*
  • Mice
  • Optical Imaging
  • Peroxynitrous Acid / analysis*
  • Reactive Oxygen Species / analysis
  • Solubility
  • Spectrometry, Fluorescence
  • Water / chemistry

Substances

  • Fluorescent Dyes
  • Reactive Oxygen Species
  • Water
  • Peroxynitrous Acid