Cognition in Patients With Newly Diagnosed Brain Metastasis: Profiles and Implications

J Neurooncol. 2014 Oct;120(1):179-85. doi: 10.1007/s11060-014-1543-x. Epub 2014 Jul 18.


Cognitive impairment is a common symptom in patients with brain metastasis, and significant cognitive dysfunction is prevalent in a majority of patients who are still able to engage in basic self-care activities. In the current study, the neurocognitive performance of 32 patients with brain metastasis and 32 demographically-matched controls was examined using a battery of standardized neuropsychological tests, with the goal of comprehensively examining the cognitive functioning of newly diagnosed brain metastasis patients. The cognition of all patients was assessed within 1 week of beginning treatment for brain metastasis. Results indicated impairments in verbal memory, attention, executive functioning, and language in relation to healthy controls. Performance in relation to appropriate normative groups was also examined. Overall, cognitive deficits were prevalent and memory was the most common impairment. Given that cognitive dysfunction was present in this cohort of patients with largely minimal functional impairment, these results have implications for patients, caregivers and health care providers treating patients with brain metastasis.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Attention / physiology
  • Brain Neoplasms / complications*
  • Brain Neoplasms / psychology
  • Brain Neoplasms / secondary
  • Brain Neoplasms / therapy
  • Case-Control Studies
  • Cognition Disorders / etiology*
  • Cognition Disorders / psychology*
  • Executive Function / physiology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Memory / physiology
  • Middle Aged
  • Neoplasm Staging
  • Neuropsychological Tests
  • Prognosis