A number of studies have linked maladaptive shame to higher levels of hypersexual behavior and tendencies to ruminate. However, little research has examined factors that may attenuate the negative impact that shame and rumination may have on hypersexuality. Drawing on data collected from male patients (N=172) assessed for hypersexual disorder in a DSM-5 field trial, path analysis was used to explore relationships among shame, rumination, self-compassion, and hypersexual behavior. The findings from this study showed that self-compassion partially mediated the relationship between shame and rumination and hypersexual behavior. The implications of these results are discussed and directions for future research are offered.