Abstract
One new (1) and three known (2-4) sesquiterpenes and four known diterpenes (5-8) were isolated from the root bark of Tripterygium hypoglaucum. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D-NMR, and 2D-NMR). The inhibitory activity toward LPS-induced NO production of these terpenoids was evaluated, all the compounds showing inhibitory effects.
Keywords:
NO production; Tripterygium hypoglaucum; terpenoid.
MeSH terms
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Animals
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Drugs, Chinese Herbal / administration & dosage
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Drugs, Chinese Herbal / chemistry
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Lipopolysaccharides / toxicity
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis*
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Nitric Oxide / metabolism
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Plant Roots / chemistry
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Sesquiterpenes / administration & dosage
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Terpenes / administration & dosage
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Terpenes / chemistry*
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Terpenes / isolation & purification
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Tripterygium / chemistry
Substances
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Drugs, Chinese Herbal
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Lipopolysaccharides
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Sesquiterpenes
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Terpenes
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Nitric Oxide