Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

J Neuroimmunol. 2014 Sep 15;274(1-2):174-9. doi: 10.1016/j.jneuroim.2014.06.024. Epub 2014 Jul 6.


Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.

Keywords: HLA; Killer cell immunoglobulin-like receptors; Multiple sclerosis; Oligoclonal bands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • HLA-DRB1 Chains / genetics*
  • HLA-DRB1 Chains / immunology
  • Haplotypes
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Antigens Class II / genetics
  • Histocompatibility Antigens Class II / immunology
  • Humans
  • Killer Cells, Natural / immunology
  • Ligands
  • Male
  • Multiple Sclerosis, Relapsing-Remitting / genetics*
  • Multiple Sclerosis, Relapsing-Remitting / immunology
  • Oligoclonal Bands / genetics*
  • Oligoclonal Bands / immunology
  • Phenotype
  • Receptors, KIR2DL1 / genetics*
  • Receptors, KIR2DL1 / immunology
  • Receptors, KIR2DL2 / genetics*
  • Receptors, KIR2DL2 / immunology
  • Receptors, KIR2DL3 / genetics*
  • Receptors, KIR2DL3 / immunology
  • Registries


  • HLA-DRB1 Chains
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • KIR2DL1 protein, human
  • KIR2DL2 protein, human
  • KIR2DL3 protein, human
  • Ligands
  • Oligoclonal Bands
  • Receptors, KIR2DL1
  • Receptors, KIR2DL2
  • Receptors, KIR2DL3