Association of serum periostin with aspirin-exacerbated respiratory disease

Ann Allergy Asthma Immunol. 2014 Sep;113(3):314-20. doi: 10.1016/j.anai.2014.06.014. Epub 2014 Jul 16.


Background: Recent studies recommend periostin as a systemic biomarker of eosinophilic airway inflammation to predict responses to novel treatments that targets eosinophilic TH2-driven inflammation in asthmatic patients.

Objective: To investigate the clinical implications of serum periostin levels in patients with aspirin-exacerbated respiratory disease (AERD) based on its overlapping TH2-mediated pathogenesis with the eosinophilic asthma.

Methods: Serum periostin levels were measured by human periostin enzyme-linked immunosorbent assay (ELISA) in serum samples from 277 adults with asthma. Serum periostin levels were compared between patients with AERD and aspirin tolerant asthma (ATA) with other asthma phenotypes, such as severe or nonsevere asthma and eosinophilic or noneosinophilic asthma. The association of serum periostin levels with clinical parameters (including disease severity and comorbid condition) was analyzed.

Results: Serum periostin levels were significantly higher in patients with AERD vs ATA, patients with severe asthma vs nonsevere asthma, and patients with eosinophilic asthma vs noneosinophilic asthma (P=.005, P=.02, and P=.001, respectively). Multivariate regression analysis revealed serum periostin levels as a significant parameter to predict AERD phenotype (P=.006) together with severe asthma phenotype (P=.04). In addition, serum periostin levels correlated with blood eosinophil counts (Spearman ñ = 0.244, P<.001) and sputum eosinophil counts (Spearman ñ = 0.261, P < 0.001). Higher serum periostin levels were noted in comorbid AERD patients with more severe chronic rhinosinusitis (Lund-Mackay stages 3 and 4) than those with less severe chronic rhinosinusitis (Lund-Mackay stages 1 and 2) (P = .03).

Conclusion: Serum periostin levels are significantly elevated in AERD patients and associated with AERD phenotype and disease severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asthma, Aspirin-Induced / blood*
  • Asthma, Aspirin-Induced / diagnosis
  • Biomarkers / blood
  • Bronchial Provocation Tests
  • Cell Adhesion Molecules / blood*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Phenotype
  • ROC Curve
  • Retrospective Studies
  • Severity of Illness Index


  • Biomarkers
  • Cell Adhesion Molecules
  • POSTN protein, human