Scutellaria prostrata (Lamiaceae), a perennial herb growing as a lonely species in Kashmir, Himalayas, was subjected to repetitive column and flash chromatographic isolation for its chemical documentation-cum-bioevaluation. The methanolic extract of S.prostrata afforded the isolation of ten compounds (1-10), including two new compounds - scutellapbiflavanone (1) and scutellaprostin M (2). The known compounds were found to be scutellarin (3), hispidulin-7-O-β-D-glucopyranoside (4), baicalin (5), wogonoside (6), scutellaprostin C (7), acetoside (8), martynoside (9) and scutellaric acid-3-O-β-D-glucopyranoside (10). Isolation of biflavonoids, phenolics and phenylethanoid compounds from S. prostrata seals a deal of chemotaxonomic importance of this particular species. The characterisation of the compounds was achieved by (1)H, (13)C, (1)H-(1)H DFQ COSY, HMBC, HSQC, HMQC and ROESY NMR experiments. All the compounds were tested for antioxidant, antimicrobial and cytotoxic activities.
Keywords: Scutellariaprostrata; antimicrobial; antioxidant; biflavonoids; cytotoxic activity; phenolics; phenylethanoids.