Integrative genomic and transcriptomic characterization of papillary carcinomas of the breast

Mol Oncol. 2014 Dec;8(8):1588-602. doi: 10.1016/j.molonc.2014.06.011. Epub 2014 Jun 26.


Papillary carcinoma (PC) is a rare type of breast cancer, which comprises three histologic subtypes: encapsulated PC (EPC), solid PC (SPC) and invasive PC (IPC). Microarray-based gene expression and Affymetrix SNP 6.0 gene copy number profiling, and RNA-sequencing revealed that PCs are luminal breast cancers that display transcriptomic profiles distinct from those of grade- and estrogen receptor (ER)-matched invasive ductal carcinomas of no special type (IDC-NSTs), and that the papillary histologic pattern is unlikely to be underpinned by a highly recurrent expressed fusion gene or a highly recurrent expressed mutation. Despite displaying similar patterns of gene copy number alterations, significant differences in the transcriptomic profiles of EPCs, SPCs and IPCs were found, and may account for their different histologic features.

Keywords: Fusion gene; Microarrays; Mutation; RNA-sequencing; Single nucleotide polymorphism arrays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism*
  • Carcinoma, Papillary / genetics*
  • Carcinoma, Papillary / metabolism*
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic / genetics
  • Gene Expression Regulation, Neoplastic / physiology
  • Genomics / methods*
  • Humans
  • Immunohistochemistry
  • In Vitro Techniques
  • Polymorphism, Single Nucleotide / genetics