Surgery for primary hyperparathyroidism

Cancer. 2014 Dec 1;120(23):3602-16. doi: 10.1002/cncr.28891. Epub 2014 Jul 9.


In the Western world, primary hyperparathyroidism is now a relatively common disorder that is diagnosed in 0.7% of the general population and in 2% of postmenopausal women. Although patients today typically present with less severe manifestations of disease, the evaluation and management of patients with parathyroid disease remains challenging. Primary hyperparathyroidism is a complex disease process that requires careful diagnosis and thoughtful medical and surgical management. The surgical management of patients with persistent or recurrent disease, inherited primary hyperparathyroidism syndromes, and parathyroid carcinoma is particularly challenging. High-quality imaging and reliable intraoperative adjuncts are critical to success.

Keywords: minimally invasive surgery; parathyroid surgery; parathyroidectomy; primary hyperparathyroidism; reopertive parathyroidectomy.

Publication types

  • Review

MeSH terms

  • Adenoma / diagnosis
  • Adenoma / surgery*
  • Humans
  • Hyperparathyroidism, Primary / diagnosis
  • Hyperparathyroidism, Primary / surgery*
  • Parathyroid Glands / diagnostic imaging
  • Parathyroid Glands / surgery*
  • Parathyroid Neoplasms / diagnosis
  • Parathyroid Neoplasms / surgery*
  • Parathyroidectomy / methods*
  • Radiopharmaceuticals
  • Technetium Tc 99m Sestamibi
  • Tomography, Emission-Computed, Single-Photon
  • Ultrasonography


  • Radiopharmaceuticals
  • Technetium Tc 99m Sestamibi