Foreign- vs US-born Asians and the association of type I uterine cancer

Am J Obstet Gynecol. 2015 Jan;212(1):43.e1-6. doi: 10.1016/j.ajog.2014.07.019. Epub 2014 Jul 17.

Abstract

Objective: The purpose of this study was to determine the association of type I endometrioid uterine cancer in US-born vs immigrant Asian women.

Study design: Data were obtained from the Surveillance, Epidemiology, and End Results Program from 2001-2009. Chi-squared, Kaplan-Meier, and binomial logistic regression analyses were used for statistics.

Results: Of 4834 Asian women with uterine cancer, 62% were US-born and 38% were immigrants. Of these women, 2972 (61%) had type I (grade 1 or 2, endometrioid histologic type) uterine cancer. Compared with patients with type II disease (grade 3, clear cell and serous histologic type), patients with type I disease were younger (age 55 vs 59 years; P < .01) and had lower stage disease (90% vs 71%; P < .01). US-born Asian women had a significantly higher proportion of type I uterine cancers in contrast to their immigrant counterparts (65% vs 56%; P < .01). Of all immigrants, the proportion of type I cancers was lowest in Japanese women followed by Chinese and Filipino women, respectively (48% vs 52% vs 58%; P < .01). The 5-year disease-specific survivals of US-born vs immigrant Asian women with type I cancer was 92% for both groups. Over 3 time periods (2001-2003, 2004-2006, and 2007-2009), there was an increase in type I cancers among US-born Asian women (61% to 65% to 68%; P < .01).

Conclusion: US-born Asian women are more likely to be diagnosed with type I uterine cancer compared with immigrants. Over the study period, there was a trend towards an increase in type I cancers among US-born Asian women.

Keywords: Asian; birthplace; endometrial cancer; ethnicity; type I cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Asia / ethnology
  • Asian Americans
  • Carcinoma, Endometrioid / epidemiology*
  • Emigrants and Immigrants*
  • Female
  • Humans
  • Middle Aged
  • Retrospective Studies
  • Uterine Neoplasms / epidemiology*
  • Young Adult