Pre-operative ⁶⁸Ga-DOTANOC somatostatin receptor PET/CT imaging demonstrating multiple synchronous lesions in a patient with head and neck paraganglioma

Rev Esp Med Nucl Imagen Mol. 2014 Nov-Dec;33(6):374-7. doi: 10.1016/j.remn.2013.11.002. Epub 2014 Jul 17.

Abstract

Paragangliomas, or glomus tumors, are neoplasms arising from extra-adrenal chromaffin tissue. They frequently cause symptoms by over-production of catecholamines with known predilection to multicentricity. We describe the case of a patient with bilateral carotid body tumor who underwent a preoperative ⁶⁸Gallium labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-Octreotide (⁶⁸Ga-DOTANOC) positron emission tomography/computed tomography (PET/CT) imaging for staging. This is a unique case in which multiple paraganglioma and pheochromocytoma were demonstrated in a single patient using ⁶⁸Ga-DOTANOC PET/CT.

Keywords: (68)Ga-DOTANOC; (68)Ga-tetraaza ciclododecano ácido tetraacético-Nal (3)-octreótido; (68)Ga-tetraazacyclododecane tetraacetic acid-Nal(3)-octreotide; Carotid body tumor; Gammagrafía; PET/CT; PET/TC; Paraganglioma; Radionuclide imaging; Tumor del cuerpo carotídeo.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Neoplasms / chemistry
  • Abdominal Neoplasms / diagnostic imaging
  • Adrenal Gland Neoplasms / chemistry
  • Adrenal Gland Neoplasms / diagnostic imaging*
  • Carotid Body Tumor / chemistry
  • Carotid Body Tumor / diagnostic imaging*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Mediastinal Neoplasms / chemistry
  • Mediastinal Neoplasms / diagnostic imaging
  • Middle Aged
  • Multimodal Imaging
  • Neoplasm Proteins / analysis
  • Neoplasms, Multiple Primary / chemistry
  • Neoplasms, Multiple Primary / diagnostic imaging*
  • Organometallic Compounds / analysis*
  • Paraganglioma / chemistry
  • Paraganglioma / diagnostic imaging*
  • Pheochromocytoma / chemistry
  • Pheochromocytoma / diagnostic imaging*
  • Positron Emission Tomography Computed Tomography*
  • Preoperative Care
  • Radiopharmaceuticals / analysis*
  • Receptors, Somatostatin / analysis
  • Sensitivity and Specificity
  • Whole Body Imaging

Substances

  • 68Ga-DOTANOC
  • Neoplasm Proteins
  • Organometallic Compounds
  • Radiopharmaceuticals
  • Receptors, Somatostatin