Base motif recognition and design of DNA templates for fluorescent silver clusters by machine learning

Adv Mater. 2014 Sep 3;26(33):5839-45. doi: 10.1002/adma.201401402. Epub 2014 Jul 14.


Discriminative base motifs within DNA templates for fluorescent silver clusters are identified using methods that combine large experimental data sets with machine learning tools for pattern recognition. Combining the discovery of certain multibase motifs important for determining fluorescence brightness with a generative algorithm, the probability of selecting DNA templates that stabilize fluorescent silver clusters is increased by a factor of >3.

Keywords: DNA nanotechnology; base motifs; fluorescent silver clusters; ligand-stabilized clusters; machine learning.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Artificial Intelligence*
  • Base Sequence
  • DNA / chemistry*
  • Fluorescence*
  • Pattern Recognition, Automated / methods*
  • Silver Compounds / chemistry*
  • Spectrometry, Fluorescence


  • Silver Compounds
  • DNA