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Review
, 6 (6), 532-47

Nanoparticle Approaches Against Bacterial Infections

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Review

Nanoparticle Approaches Against Bacterial Infections

Weiwei Gao et al. Wiley Interdiscip Rev Nanomed Nanobiotechnol.

Abstract

Despite the wide success of antibiotics, the treatment of bacterial infections still faces significant challenges, particularly the emergence of antibiotic resistance. As a result, nanoparticle drug delivery platforms including liposomes, polymeric nanoparticles, dendrimers, and various inorganic nanoparticles have been increasingly exploited to enhance the therapeutic effectiveness of existing antibiotics. This review focuses on areas where nanoparticle approaches hold significant potential to advance the treatment of bacterial infections. These areas include targeted antibiotic delivery, environmentally responsive antibiotic delivery, combinatorial antibiotic delivery, nanoparticle-enabled antibacterial vaccination, and nanoparticle-based bacterial detection. In each area we highlight the innovative antimicrobial nanoparticle platforms and review their progress made against bacterial infections.

Figures

Figure 1
Figure 1
Schematic illustration of major nanoparticle-based delivery platforms for treating bacterial infections: (A) liposome, (B) polymeric nanoparticle, (C) dendrimer, and (D) inorganic nanoparticle.
Figure 2
Figure 2
Schematic illustration of a phospholipid liposome stabilized by charged gold nanoparticles and its drug release in response to pH change or the presence of bacterial toxin.
Figure 3
Figure 3
Schematic preparation of nanoparticle-detained toxins, denoted ‘nanotoxoid’, consisting of substrate-supported RBC membranes into which pore-forming toxins can spontaneously incorporate. Reproduced with permission from reference .
Figure 4
Figure 4
Schematic illustration of interbilayer-crosslinked multilamellar vesicles (ICMVs) for vaccine delivery: (A) OVA-loaded ICMVs with MPLA only on the external surface, and (B) OVA-loaded ICMVs with MPLA throughout the lipid multilayers. Reproduced with permission from reference .
Figure 5
Figure 5
Magneto-DNA assay for the detection of bacterial 16S rRNA. Total RNA is extracted from the specimen, and the 16S rRNA is amplified by asymmetric RT-PCR. Single-strand DNA of the amplified product is then captured by beads conjugated with capture probes, followed by hybridizing with MNPs to form a magnetic sandwich complex. Samples are subsequently analyzed using a miniaturized micro-NMR (μNMR) system. Reproduced with permission from reference .

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