Functional roles of Syk in macrophage-mediated inflammatory responses

Mediators Inflamm. 2014;2014:270302. doi: 10.1155/2014/270302. Epub 2014 Jun 18.

Abstract

Inflammation is a series of complex biological responses to protect the host from pathogen invasion. Chronic inflammation is considered a major cause of diseases, such as various types of inflammatory/autoimmune diseases and cancers. Spleen tyrosine kinase (Syk) was initially found to be highly expressed in hematopoietic cells and has been known to play crucial roles in adaptive immune responses. However, recent studies have reported that Syk is also involved in other biological functions, especially in innate immune responses. Although Syk has been extensively studied in adaptive immune responses, numerous studies have recently presented evidence that Syk has critical functions in macrophage-mediated inflammatory responses and is closely related to innate immune response. This review describes the characteristics of Syk-mediated signaling pathways, summarizes the recent findings supporting the crucial roles of Syk in macrophage-mediated inflammatory responses and diseases, and discusses Syk-targeted drug development for the therapy of inflammatory diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation / immunology*
  • Inflammation / metabolism*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Macrophages / metabolism*
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction / physiology
  • Syk Kinase

Substances

  • Intracellular Signaling Peptides and Proteins
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase