Clinical effectiveness of non-invasive selective cryolipolysis

J Cosmet Laser Ther. 2014 Oct;16(5):209-13. doi: 10.3109/14764172.2014.946050. Epub 2014 Aug 13.


Background: Excess subcutaneous fat causes not only cosmetic issues, but also substantial systemic health problems. Cryolipolysis has been reported to provide non-invasive fat reduction that significantly reduces subcutaneous fat cells with controlled, localized cooling.

Objective: This study is intended to determine whether a cryolipolysis device can effectively reduce subcutaneous fat without damaging the overlying skin or causing significant side effects and ultimately produce improved cosmetic results.

Materials and methods: A total of 15 patients participated in this study and they were treated unilaterally in a split-body trial manner with a non-invasive cryolipolysis device (Micool(™), Hironic Co., Seongnam, Korea). The degree of improvement was assessed by both objective and subjective assessments. Complications and side effects were recorded at every visit.

Results: The results of both objective and subjective assessments showed significant improvements in subcutaneous fat reduction without any meaningful complications.

Conclusion: Non-invasive selective cryolipolysis has been reported to be a safe and effective treatment modality for the reduction of excess adipose tissue. Therefore, cryolipolysis is a promising technology that could be an appropriate and safe therapeutic option for subcutaneous fat reduction.

Keywords: cryolipolysis; fat removal.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cryotherapy / methods*
  • Female
  • Humans
  • Lipectomy / methods*
  • Male
  • Patient Satisfaction
  • Republic of Korea
  • Subcutaneous Fat / surgery*