Extracellular matrix regulation in the muscle satellite cell niche

Connect Tissue Res. 2015 Feb;56(1):1-8. doi: 10.3109/03008207.2014.947369. Epub 2014 Aug 12.


Increasing evidence points to extracellular matrix (ECM) components playing integral roles in regulating the muscle satellite cell (SC) niche. Even small alterations to the niche ECM can have profound effects on SC localization, activation, self-renewal, proliferation and differentiation. This review will focus on the ECM components that comprise the niche, how they are modulated in health and disease and how these changes are thought to affect SC function. Particular emphasis will be placed on the pathological niche and interventions that aim to restore healthy structure and function, as a better understanding of the interplay between the SC and its environment will drive more targeted and effective therapies.

Keywords: Basement membrane; collagen; proteoglycan; satellite cell; stem cell.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Extracellular Matrix / metabolism*
  • Humans
  • Models, Biological
  • Satellite Cells, Skeletal Muscle / cytology
  • Satellite Cells, Skeletal Muscle / metabolism*
  • Stem Cell Niche*
  • Stem Cell Transplantation