Photodynamic therapy plus topical retinoids in Darier's disease

Photodiagnosis Photodyn Ther. 2007 Mar;4(1):36-8. doi: 10.1016/j.pdpdt.2006.09.002. Epub 2006 Nov 1.


Darier's disease is a rare, genetically determined, chronic disorder of keratinization. Characterized clinically by a symmetrical eruption of hypercheratotic papules with predilection for the seborrhoeic areas of the body. Many treatments have been suggested: emollients, topical retinoids, dermoabrasion, topical steroids and intermittent courses of oral antibiotics. Systemic retinoids are usually the treatment of choice. We present a small case series of patients treated with PDT and topical retinoids with good results. This therapeutic modality could represent an alternative to systemic retinoid treatment.