EGFR-mutated lung cancer in Li-Fraumeni syndrome

Lung Cancer. 2014 Sep;85(3):485-7. doi: 10.1016/j.lungcan.2014.06.017. Epub 2014 Jun 30.

Abstract

This is a revised case report of a 52 year old Caucasian female with Li-Fraumeni syndrome with a rare TP53 mutation, who was treated for breast cancer and later developed epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer.

Keywords: EGFR mutations; Li-Fraumeni syndrome; Non-small cell lung cancer; TP53.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery
  • DNA Mutational Analysis
  • ErbB Receptors / genetics*
  • Erlotinib Hydrochloride
  • Female
  • Humans
  • Li-Fraumeni Syndrome / complications*
  • Li-Fraumeni Syndrome / genetics*
  • Lung Neoplasms / complications*
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / genetics*
  • Middle Aged
  • Mutation*
  • Quinazolines / therapeutic use
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Tumor Suppressor Protein p53 / genetics
  • Young Adult

Substances

  • Quinazolines
  • Tumor Suppressor Protein p53
  • Erlotinib Hydrochloride
  • ErbB Receptors