Virus meets host microRNA: the destroyer, the booster, the hijacker

Yang Eric Guo; Joan A Steitz

doi:10.1128/MCB.00871-14

Virus meets host microRNA: the destroyer, the booster, the hijacker

Mol Cell Biol. 2014 Oct;34(20):3780-7. doi: 10.1128/MCB.00871-14. Epub 2014 Jul 21.

Authors

Yang Eric Guo¹, Joan A Steitz²

Affiliations

¹ Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, USA Howard Hughes Medical Institute Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
² Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut, USA Howard Hughes Medical Institute Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA joan.steitz@yale.edu.

Abstract

Virus-host interactions highlight key regulatory steps in the control of gene expression. MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein production via base pairing with mRNAs. Both DNA and RNA viruses have evolved mechanisms to degrade, boost, or hijack cellular miRNAs to benefit the viral life cycle. This minireview focuses on recent discoveries in virus-host miRNA interactions.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Base Sequence
Encephalitis Virus, Eastern Equine / physiology
Gene Expression Regulation, Viral
Herpesviridae / physiology*
Host-Pathogen Interactions*
Humans
MicroRNAs / genetics*
MicroRNAs / metabolism
Poxviridae / physiology*
RNA Interference
RNA Stability

Substances

MicroRNAs

Abstract

Publication types

MeSH terms

Substances

Grants and funding