The Role of interleukin-1 Family Members in the Host Defence Against Aspergillus Fumigatus

Mycopathologia. 2014 Dec;178(5-6):395-401. doi: 10.1007/s11046-014-9776-y. Epub 2014 Jul 22.

Abstract

The interleukin (IL)-1 family consists of 11 members, which all play significant roles in regulating inflammatory responses in the host. IL-1α and IL-1β exert potent pro-inflammatory effects and are key players in the recruitment of neutrophils to the site of inflammation. Protective anti-Aspergillus host responses during the early stages of invasive aspergillosis are critically dependent on neutrophil recruitment, and several lines of evidence support that there is an important role for IL-1 in this process. However, IL-1-mediated inflammation needs to be tightly regulated, since uncontrolled inflammation can result in inflammatory pathology and thereby be detrimental for the host. Aspergillus-induced IL-1-mediated inflammation could therefore be amendable for IL-1 blockade under specific circumstances. This review describes the current understanding of the role of IL-1 family members in the host response against Aspergillus fumigatus and highlights the importance of balanced IL-1 responses in aspergillosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aspergillosis / immunology*
  • Aspergillus fumigatus / immunology*
  • Humans
  • Interleukin-1 / immunology*
  • Neutrophils / immunology

Substances

  • Interleukin-1