Studies on the kinetics of carbamazepine degradation in aqueous matrix in the course of modified Fenton's reactions

Agnieszka Karpinska; Aneta Sokół; Joanna Karpinska

doi:10.1016/j.jpba.2014.06.033

Studies on the kinetics of carbamazepine degradation in aqueous matrix in the course of modified Fenton's reactions

J Pharm Biomed Anal. 2015 Mar 15:106:46-51. doi: 10.1016/j.jpba.2014.06.033. Epub 2014 Jul 2.

Authors

Agnieszka Karpinska¹, Aneta Sokół¹, Joanna Karpinska²

Affiliations

¹ Institute of Chemistry, University of Bialystok, Poland.
² Institute of Chemistry, University of Bialystok, Poland. Electronic address: joasia@uwb.edu.pl.

PMID: 25049061
DOI: 10.1016/j.jpba.2014.06.033

Abstract

The present article describes a study into the kinetics of carbamazepine degradation under influence of the standard Fenton's reagent, light-enhanced Fenton's reagent, as well as modified Fenton's systems in which iron(II) ion is replaced by Cu(I), Cu(II), Ni(II), Mn(II), Cr(III) and V(V) ions. In the course of the study it was established that V(V) ion modified Fenton's reagent was equally effective in relation to carbamazepine as the standard reagent. Parameters of both standard and modified Fenton's reagents were optimized. It was observed that an increased concentration of inorganic ions and acidic pH levels precipitated the decomposition of carbamazepine.

Keywords: Carbamazepine; Fenton reagent; Kinetics of reaction; Modified Fenton reagent; Photodegradation.

MeSH terms

Anticonvulsants / chemistry*
Carbamazepine / chemistry*
Hydrogen Peroxide / chemistry*
Hydrogen-Ion Concentration
Iron / chemistry*
Kinetics
Water / chemistry*

Substances

Anticonvulsants
Fenton's reagent
Water
Carbamazepine
Hydrogen Peroxide
Iron