The genetics of position-effect variegation modifying loci in Drosophila melanogaster

Mol Gen Genet. 1989 Jun;217(2-3):520-7. doi: 10.1007/BF02464926.

Abstract

The dose dependent effects of position-effect variegation (PEV) modifying genes were studied in chromosome arms 2L, 2R and 3R. Four groups of PEV modifying genes can be distinguished: haplo-abnormal suppressor and enhancer loci with or without a triplo-effect. Using duplications four triplo-abnormal suppressor and four triplo-abnormal enhancer functions were localized. In two cases we proved that these functions correspond to a converse haplo-abnormal one. Altogether 43 modifier loci were identified. Most of these loci proved not to display significant triplo-effects (35). The group of haplo-abnormal loci with a triplo-effect may represent genes which play an important role in heterochromatin packaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping
  • Drosophila melanogaster / genetics*
  • Enhancer Elements, Genetic
  • Gene Expression Regulation*
  • Heterochromatin / genetics
  • Suppression, Genetic

Substances

  • Heterochromatin