Sex in flies: the splice of life

Nature. 1989 Aug 17;340(6234):521-4. doi: 10.1038/340521a0.


The discovery that the primary transcripts of many genes are processed to produce more than one kind of messenger RNA focuses attention on the control of RNA processing as a developmental regulatory mechanism. In the fruit-fly Drosophila melanogaster, differential splicing of a hierarchy of regulatory genes determines sex, and thus the molecular biology of sex determination in the fruit-fly may lead to insights into the mechanisms by which alternative splicing is regulated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Chromosome Mapping
  • Drosophila melanogaster / genetics*
  • Female
  • Genes, Regulator
  • Male
  • RNA Splicing*
  • Sex Determination Analysis*