P granules

doi:10.1016/j.cub.2014.06.018

. 2014 Jul 21;24(14):R637-R638.

doi: 10.1016/j.cub.2014.06.018.

P granules

Jennifer T Wang¹, Geraldine Seydoux²

Affiliations

¹ Department of Molecular Biology and Genetics, HHMI, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Molecular Biology and Genetics, HHMI, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: gseydoux@jhmi.edu.

PMID: 25050955
PMCID: PMC4966529
DOI: 10.1016/j.cub.2014.06.018

Free PMC article

P granules

Jennifer T Wang et al. Curr Biol. 2014.

Free PMC article

. 2014 Jul 21;24(14):R637-R638.

doi: 10.1016/j.cub.2014.06.018.

Authors

Jennifer T Wang¹, Geraldine Seydoux²

Affiliations

¹ Department of Molecular Biology and Genetics, HHMI, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Molecular Biology and Genetics, HHMI, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: gseydoux@jhmi.edu.

PMID: 25050955
PMCID: PMC4966529
DOI: 10.1016/j.cub.2014.06.018

No abstract available

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Figures

**Figure 1. P granules**
P granules (detected using the OIC1D4 antibody) in an adult hermaphrodite gonad. P granules are perinuclear in germ cells in the pachytene and diplotene stages of meiosis and become progressively more cytoplasmic in growing oocytes. The inset at top right shows cytoplasmic P granules (detected with an anti-GLH-2 antibody) in an embryo in the first mitotic prophase: these P granules are enriched on the posterior side. P granules are in green, and DNA is in blue. Scale bar = 1 µm. (Image: Jennifer T. Wang.)

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References

1. Brangwynne CP, Eckmann CR, Courson DS, Rybarska A, Hoege C, Gharakhani J, Julicher F, Hyman AA. Germline P granules are liquid droplets that localize by controlled dissolution/condensation. Science. 2009;324:1729–1732. - PubMed
1. Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, et al. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009;139:123–134. - PMC - PubMed
1. Gallo CM, Wang JT, Motegi F, Seydoux G. Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans. Science. 2010;330:1685–1689. - PMC - PubMed
1. Hanazawa M, Yonetani M, Sugimoto A. PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans. J. Cell Biol. 2011;192:929–937. - PMC - PubMed
1. Sheth U, Pitt J, Dennis S, Priess JR. Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells. Development. 2010;137:1305–1314. - PMC - PubMed

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[1] Brangwynne CP, Eckmann CR, Courson DS, Rybarska A, Hoege C, Gharakhani J, Julicher F, Hyman AA. Germline P granules are liquid droplets that localize by controlled dissolution/condensation. Science. 2009;324:1729–1732. - PubMed

[2] Brangwynne CP, Eckmann CR, Courson DS, Rybarska A, Hoege C, Gharakhani J, Julicher F, Hyman AA. Germline P granules are liquid droplets that localize by controlled dissolution/condensation. Science. 2009;324:1729–1732. - PubMed

[3] Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, et al. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009;139:123–134. - PMC - PubMed

[4] Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, et al. The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell. 2009;139:123–134. - PMC - PubMed

[5] Gallo CM, Wang JT, Motegi F, Seydoux G. Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans. Science. 2010;330:1685–1689. - PMC - PubMed

[6] Gallo CM, Wang JT, Motegi F, Seydoux G. Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans. Science. 2010;330:1685–1689. - PMC - PubMed

[7] Hanazawa M, Yonetani M, Sugimoto A. PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans. J. Cell Biol. 2011;192:929–937. - PMC - PubMed

[8] Hanazawa M, Yonetani M, Sugimoto A. PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans. J. Cell Biol. 2011;192:929–937. - PMC - PubMed

[9] Sheth U, Pitt J, Dennis S, Priess JR. Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells. Development. 2010;137:1305–1314. - PMC - PubMed

[10] Sheth U, Pitt J, Dennis S, Priess JR. Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells. Development. 2010;137:1305–1314. - PMC - PubMed

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P granules

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