[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon]

Adv Gerontol. 2014;27(1):94-7.
[Article in Russian]


While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level. With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.

MeSH terms

  • Acute Disease
  • Animals
  • Apoptosis / drug effects
  • Brain / drug effects
  • Brain / metabolism*
  • Brain / pathology
  • Caspase 3 / metabolism*
  • Disease Models, Animal
  • Hypoxia* / metabolism
  • Hypoxia* / pathology
  • Hypoxia* / physiopathology
  • Intercellular Signaling Peptides and Proteins
  • Interleukin-6 / metabolism*
  • Male
  • Neurogenesis / drug effects
  • Oligopeptides / pharmacology*
  • Peptides / pharmacology*
  • Rats
  • Tumor Necrosis Factor-alpha / metabolism


  • Intercellular Signaling Peptides and Proteins
  • Interleukin-6
  • Oligopeptides
  • Peptides
  • Tumor Necrosis Factor-alpha
  • pinealon
  • cortexin
  • Caspase 3