Regulating the diverse outcomes of interferon's interference

Trends Immunol. 2014 Aug;35(8):353-4. doi: 10.1016/ Epub 2014 Jul 19.


Regulatory T cells are crucial for preventing autoimmunity, but how their function is restrained to allow optimal effector T cells responses in appropriate contexts is unclear. In a recent paper in the Journal of Experimental Medicine, Campbell and colleagues demonstrate that virus-induced type I interferon acts directly on Treg cells to allow for functional antiviral T cell responses.

Publication types

  • Introductory Journal Article

MeSH terms

  • Animals
  • Cytotoxicity, Immunologic
  • Humans
  • Immune Tolerance
  • Immunologic Memory
  • Interferon Type I / immunology*
  • Mice
  • Mice, Knockout
  • STAT Transcription Factors / metabolism
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / virology
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / virology
  • Virus Diseases / immunology*


  • Interferon Type I
  • STAT Transcription Factors