Molecular Dosimetry of Hepatic Aflatoxin B1-DNA Adducts: Linear Correlation With Hepatic Cancer Risk

Regul Toxicol Pharmacol. 1989 Aug;10(1):74-81. doi: 10.1016/0273-2300(89)90014-7.

Abstract

An analysis of hepatic aflatoxin B1-DNA adduct (HADA) concentrations in rats and trout demonstrated that the hepatic cancer risk was linearly and quantitatively related in both species. Additionally, the adduct-risk correlation for short-term exposure accurately predicted chronic exposure risk in trout. Although rat and trout liver cells differ substantially in their nuclear DNA content, they appeared to experience similar cancer risks at a given HADA concentration. This may indicate that the liver nuclei of both species contain a similar number of an equivalent protooncogene(s). This analysis also provided a possible basis for the use of adduct measurements for estimating human cancer risk. The minimum human virtual safe dose for aflatoxin was estimated to be 0.264 ng/kg/day on the basis of this approach.

Publication types

  • Review

MeSH terms

  • Aflatoxin B1
  • Aflatoxins / toxicity*
  • Animals
  • DNA / analysis*
  • DNA / drug effects
  • Humans
  • Liver Neoplasms / chemically induced*
  • Risk Factors

Substances

  • Aflatoxins
  • DNA
  • Aflatoxin B1