The oncogene jun and nuclear signalling

Trends Biochem Sci. 1989 May;14(5):172-5. doi: 10.1016/0968-0004(89)90268-5.

Abstract

Jun is a transcription factor that can also induce oncogenic transformation. Its DNA-binding domain is conserved from yeast to man and shows homology to several other transcriptional regulators. Jun dimerizes with the fos protein through an alpha-helical domain termed the leucine zipper, and the jun-fos heterodimers bind to DNA and regulate transcription of numerous specific unlinked genes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • Humans
  • Oncogene Protein p65(gag-jun)
  • Retroviridae Proteins / metabolism*

Substances

  • DNA-Binding Proteins
  • Oncogene Protein p65(gag-jun)
  • Retroviridae Proteins