The Drosophila zeste gene and transvection

Trends Genet. 1989 Jun;5(6):189-94. doi: 10.1016/0168-9525(89)90074-7.


The zeste locus of Drosophila melanogaster encodes a DNA-binding protein that can influence transcription. A number of sites recognized by this protein fall within genes associated with transvection, a phenomenon suggesting a form of gene regulation that is responsive to the proximity of a gene to its homologous allele on another chromosome. These recent observations continue a history of studies concerning zeste and transvection which has inspired molecular models linking chromosome structure and positioning to the modulation of gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Chromosomes
  • DNA-Binding Proteins / genetics*
  • Drosophila Proteins
  • Drosophila melanogaster / genetics*
  • Eye Color / genetics
  • Gene Expression Regulation*
  • Models, Genetic
  • Molecular Sequence Data


  • DNA-Binding Proteins
  • Drosophila Proteins
  • z protein, Drosophila